較冷的方式來評估腦部手術的病人

A Cooler Way to Evaluate Brain Surgery Patients

評估神經外科患者的新方法提供了新的洞察大腦如何產生的講話


技術Guardian.co.uk這篇文章題為 “評估腦部手術的病人的冷卻器方式” 寫由莫Costandi, 對於theguardian.com週五2月26日上 2016 09.30 世界標準時間

在中美研究者. 已經開發出用於映射在有知覺患者即將經受神經外科一種新的和改進的技術,保護腦功能 - 通過冷卻小, 本地化的大腦區域暫時中斷自己的工作方式和映射字形成所需的區域和語言的時機. 他們描述他們的方法, 並解釋如何用它來研究生產口語基礎的腦機制, 在一項新的研究剛剛發表在雜誌 神經元.

關於人的故事誰留 甦醒腦部手術 經常出現在大眾媒體. 在 2008, 例如, multiple news outlets reported that legendary Bluegrass musician Eddie Adcock not only remained conscious, but also played his banjo, during a three-and-a-half operation to treat a hand tremor. And last December, there were similar reports about the Spanish jazz musician Carlos Aguilera, 誰 played his saxophone throughout a 12-hour operation to remove a brain tumour.

Such procedures are often described as “astonishing,” “revolutionary,” and, 有時, “miraculous.” In fact, surgeons have been operating on the brains of conscious patients for nearly one hundred years: The method was developed in the 1920s by the pioneering Canadian neurosurgeon Wilder Penfield, as a way of locating the abnormal brain tissue causing epileptic seizures.

Penfield used electrodes to stimulate the surface of his patients’ brains, and deliberately kept them awake during surgery so that they could report the effects of the stimulation back to him. By stimulating the areas around the abnormal tissue, he could identify the tissue causing the seizures while also determining which of the surrounding areas are crucial for important functions like speech and movement. 這條路, he could remove the abnormal tissue without causing any collateral damage.

Penfield’s method of cortical stimulation is still used widely today but, somewhat ironically, can itself trigger epileptic seizures. The new method carries no such risk. Developed by Michael Long of New York University’s Langone Medical Center and his colleagues, it builds on an earlier method that used cooling probes to study the brain circuitry responsible for song production in zebra finches.

Long and his colleagues used a similar cooling device on 16 patients being evaluated for neurosurgical operations to treat their drug-resistant epilepsy. With the patients under local anaesthetic, the researchers used the device to cool 42 discrete brain regions, all of which have been previously implicated in speech production, by about 10°C each. 與此同時, the patients were asked to recite the days of the week, or a simple string of numbers, so that their speech function could be assessed while each region was cooled.

Cooling interrupts cellular activity, 在某些情況下, the researchers found that it interfered with the patients’ ability to speak, slowing and blurring their speech. This effect was only temporary, however – brain function returned to normal immediately after the cooling device was removed from the brain, and all 16 patients subsequently recovered from their operations without any undesired side effects or other complications.

The results confirm earlier findings that the brain areas involved in speech production are mostly confined to the left hemisphere, and they also provide new insights into how the brain produces speech. 特別, cooling a specific part of the left motor cortex altered the quality of the patients’ speech, whereas cooling of Broca’s Area in the left temporal lobe altered the timing of their speech.

These results shows that the motor cortex directs the muscle movements in the lips and tongue that are required for articulating speech, whereas Broca’s Area is needed for executing these movements in their proper sequence.

“This study confirms that cooling is a safe and effective means of protecting important brain centers during neurosurgery,” Long. “[它] also represent[小號] a major advance in the understanding of the roles played by the areas of the brain that enable us to form words.”

參考

Long, 中號. A., . (2016). Functional Segregation of Cortical Regions Underlying Speech Timing and Articulation. 神經元 89: 1–7. DOI: 10.1016/j.neuron.2016.01.032 [抽象]

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