Öncü kanser tedavisi mühendisleri hastalıkla mücadele için bağışıklık sistemi

Pioneering cancer treatment engineers immune systems to fight disease

 

Gardiyanın Powered byBaşlıklı makalede, bu “Öncü kanser tedavisi mühendisleri hastalıkla mücadele için bağışıklık sistemi” Harun Siddique tarafından yazılmıştır, Çarşamba 9 Aralık'ta THEGUARDIAN.COM için 2015 14.50 UTC

Baş ve boyun kanserli hastalar hastalığın savaş onların bağışıklık sistemlerini isteyen içeren bir çığır açan yeni bir tedavi gören.

deneme, at Sağlık Araştırmaları biyomedikal araştırma merkezi Ulusal Enstitüsü Guy ve St Thomas 'NHS Foundation Trust ve King College London'da, Onlar tanımak ve tümör saldırı böylece genetik modifiye hastaların beyaz kan hücrelerini içerir.

Özellikle enfekte olanlar - - bağışıklık sisteminin Beyaz kan hücreleri doğal hücreleri ortadan kaldırmak için donanımlı orada olmamalı, ama bazen tanımak ve saldırı kanser hücrelerinin için yardıma ihtiyacım var.

Bir kan örneği kullanarak, the BRC team is treating white blood cells in the laboratory with a harmless virus that introduces two new genes. The first gene makes it easier to grow the cells during their time in the laboratory while the second enables the white blood cells to recognise and attack the tumour.

Principal investigator Dr John Maher said: “In most cancers, metastasis, the spread of a disease from the part of the body where it started to another not directly connected, is the commonest cause of death. Ancak, head and neck cancer is unusual in that local spread or recurrence of the disease accounts for most suffering and death. This means that tumours may become inoperable and do not shrink in response to traditional treatments such as chemotherapy or radiotherapy.”

The treatment is called a CAR T-cell and takes two weeks to produce. To maximise its safety and effectiveness the team is injecting the CAR T-cells directly into the tumour. CAR T-cell treatment has proven effective in some forms of leukaemia but the hope is that it can be developed further to benefit patients with so-called “solid cancers”, which form a discrete tumour mass, such as head and neck cancer.

Maher said success could have “significant implications for other solid cancers, especially those that spread within a natural space in the body, such as ovarian cancer (lining of the abdomen) or mesothelioma (lining of the lungs). In that setting, it may be possible to inject the CAR T-cells from the patient directly into the cavity, to localise the treatment where it is needed most”.

During the phase 1 trial, which aims to test the treatment’s safety and effectiveness, patients enrolled in groups will successively receive a higher number of cells to establish safe dosage, provided it does not produce significant side-effects. If it is successful, the treatment will need to be tested in larger numbers of patients to establish how effective it is at combating the cancer.

Dr Stephen Caddick, director of innovations at the Wellcome Trust, which co-funded the trial, adı geçen: “By precision engineering immune cells to recognise and destroy tumours, researchers are hopeful that they will be able to improve the prospects for patients who have, until now, faced very limited treatment options.”

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