kalafo la Alzheimer le kamano e haufi joalokaha ho ruruha boko bontšoa ho ba senotlolo

Alzheimer’s treatment closer as brain inflammation shown to be key

Tsa Sehlooho se Ithutoang bontša memori le mathata a boitshwaro ho ruruha-fokotsa lik'hemik'hale thibela ka litoeba kula, hōlisa tšepile hore bakeng sa kalafo botho


Tsamaisoa ka Guardian.co.ukSehlooho sena se titled “kalafo la Alzheimer le kamano e haufi joalokaha ho ruruha boko bontšoa ho ba senotlolo” e ngotsoe ke Ian Sample Science mohlophisi, etsoe The Guardian ka Labohlano bo8 January 2016 00.05 UTC

Bo-rasaense ba na le tšepile hore o hloekileng bakeng la kalafo e Alzheimer ka mor'a liteko ho fokotsa ho ruruha a boko kula toeba thibela memori le mathata a boitshwaro a liphoofolo.

lefu la Alzheimer o nako e telele nile tsa amahanngoa le qhala a sesole sa 'boko, empa se le lipatlisisong ka morao-rao eketsa bopaki ba hore ho ruruha bokong e sa le bongata hakaale bakoang ke lefu lena, empa ke mokhanni oa ho hloka taolo ya.

Bafuputsi Univesithing ea Southampton ithuta lisele tsoang boko bophelo bo botle ba batho le ba bang ba angoa ke lefu la Alzheimer. Ba ile ba fumana hore boko la Alzheimer ne lisele tse eketsehileng boitshireletso, a tsejoa e le microglia, ho feta boko ba phetseng hantle.

Bo-rasaense latelang sheba microglia a litoeba tse neng li le hlahileng ho hlaolela boemong boo tšoana lefu la Alzheimer. Letotong la liteko tlalehoa koranteng ea boko, thimi a enta litoeba le lik'hemik'hale e khaotsa ho dinomoro tsa microglia tsoang hōla holimo haholo.

A litoeba untreated, le maloetse a itseng a etsa hore lisele boko ka mokhoa o tsitsitseng lahleheloa dikgokelo bona le ba bang. Empa tšoaroa litoeba 'na dikgokelo oa sele ea bona methapo ea kutlo' me a ka tlaasenyana memori le mathata a boitshwaro. Crucially, phekolo lula maemo tloaelehileng ea microglia hlokahalang bakeng sa tsamaiso ea phetseng hantle boko boitshireletso. Ho phekola o ne a sa, leha ho le joalo, thibela haha ​​oa bath amyloid plaques a boko liphoofolo '.

Diego Gomez-Nicola, ea ileng a etella ea thuto, ile a re: liteko ne e le "haufi le bopaki bo joalokaha re ka fumana" e le hore ho ruruha le microglia ne li le bohlokoa bakeng sa kgatelopele ea lefu la Alzheimer. Thimi hona joale o rerile ho sebetsa le indasteri e etsang meriana ho fumana sethethefatsi loketseng motseng e ka lekoa bathong. The lik'hemik'hale fuoa litoeba tsa bohato leqepheng la receptor fumanoa holim'a microglia bitsoa CSFR1.

"Ena ke ntho e thabisang haholo le robust pampiri ka sehlopha se hlomphehang haholo ea bo-ramahlale,"Pauluse o itse: Morgan, motsamaisi oa Systems sireletsehile maloetseng ana Institute Research University Cardiff University o. "Fumanoeng ke The tsosa utloahalang tebello ea ho shebiloe haholo CSFR1 kenya tshebetsong ho thibela metsoako ntshetsopele ya tshwerweng ke 'dementia a batho ba nang le matšoao a pele-pele lefu la Alzheimer. Hobane lithethefatsi tse thibela metsoako CSFR1 kenya tshebetsong di se a ntse a tleliniking bakeng sa hore ditshebediso tse ding, sena e ka ba ka finyelloang ho hongata ka potlako ho feta ho qala go tswa kwa tshimologong le sethethefatsi se secha. "

Mark Dallas, e neuroscientist Univesithing Reading, re sibolloa ba ne ba hlalosa hore na ke hobane'ng lithethefatsi tse etselitsoeng ho phekola la Alzheimer ba ho fihlela joale bile boa ka ba atleha.

"Le hoja sena mambi tsa motheo e fana ka bopaki bo matla, phephetso e tla hona joale ba ho ntshetsa pele meriana bakeng sa batho ba nang le 'dementia. hangata, sena e bile ho khopiso a retelehela hlokometsoeng ka laboratoring ea ho kena le ha phekolo eo ue boloke.

"Excitingly, it does however highlight new avenues for researchers to exploit and strengthens the case for targeting other cell types within the brain in the fight against Alzheimer’s,"O ile a phaella.

Simon Ridley, director of research at Alzheimer’s Research UK, which co-funded the study, a re: “Research like this is vital as there are currently no treatments that can stop or slow the progression of Alzheimer’s disease in the brain.”

guardian.co.uk © Guardian News & Media Limited 2010

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