Cancer m'mawere Growth Cell Kuletsa ndi kufooka kwa mafupa Mankhwala

Breast Cancer Cell Growth Halted by Osteoporosis Drug

A mayesero mbewa zasonyeza kuti denosumab mankhwala kukhala ndi kuteteza m'mawere khansa mankhwala akazi ndi masinthidwe BRCA1 jini


Zoyendetsedwa ndi Guardian.co.ukNkhaniyi lotchedwa “khansa selo kukula unatha ndi kufooka kwa mafupa mankhwala, ikusonyezera kuphunzira” linalembedwa ndi Ian Chitsanzo Science mkonzi, pakuti The Guardian Lolemba 20 June 2016 15.40 UTC

Akazi amene ali ndi chiopsezo cha khansa angapindule mankhwala kale analamula kuti kuchitira imfa fupa ukalamba, monga asayansi Australia.

Ofufuza anapeza kuti kufooka kwa mafupa mankhwala, denosumab, akhoza kuletsa kukula kwa maselo amene chimayambitsa m'mawere zotupa mu akazi amene chiopsezo cha matenda ndi wamkulu chifukwa cha masinthidwe mu BRCA1 mbewu wotchedwa.

Ngakhale zingamuthandize, ntchito ndi pa siteji oyambirira ndi zotsatira tikaona mpaka mayesero labu pa mbewa ndi m'mawere minofu ayenera chinaonekeranso mwa mayesero akuluakulu anthu pamaso mankhwala tinganene kuti ngati mankhwala kuteteza.

Healthy BRCA1 ndi BRCA2 chibadwa kuthandiza DNA thupi kukonza kuonongeka. Koma pamene mwina jini mutated, chiopsezo m'mawere ndi yamchiberekero khansa akhoza adzauka steeply. Pafupifupi theka la azimayi amene adzalandira ulimi zoipa mu BRCA1 kapena BRCA2 kukhazikitsa khansa ya m'mawere ndi zaka 70.

Amene amajambula akamagwira zoipa BRCA masinthidwe akhoza kusankha kuteteza opaleshoni kuti achotse pachifuwa, kapena zambiri tima kuyezetsa magazi ndi zotupa. "Tinali kudziŵa ndi kusinthana njira, njira sanali opaleshoni akazi awa,"Anati Emma Nolan pa Walter ndi Eliza Hall Institute of Medical Research ku Victoria.

Asayansi kusanthula m'mawere minofu anapereka kwa mkazi ndi matenda masinthidwe BRCA1. pamenepa, iwo olekanitsidwa gulu lapadera la maselo unakula mofulumira ndipo zikuoneka kuti zinthu zofunika m'mawere zotupa.

mofatsa ulosi wa maselo anasonyeza kuti ananyamula pentopeni mapuloteni padziko, wotchedwa RANK1. Mapuloteni womwewo akulimbana ndi denosumab, amene kale ntchito pofuna kuchiza kufooka kwa mafupa ndi bere khansara imene yafalitsidwa ku fupa.

Mu mayesero labu lipoti mu magazini ya Nature Medicine, denosumab oletsedwa kukula kwa maselo a khansa n'zofanana ndi mochedwa kukula kwa zotupa mu mbewa zabweretsa kukhala khansa ya m'mawere.

"Ndife okondwa ndi anapezazo izi chifukwa zikutanthauza tapeza njira kuti akakhale zothandiza kupewa khansa mu akazi kwambiri chiopsezo, Makamaka BRCA1 kusintha onyamula,"Anati Geoff Lindeman, ndi oncologist zachipatala pa Royal Melbourne Hospital. Iye anati chiyeso matenda kuwunika mankhwala odwala kale anayamba.

Emma Smith pa Cancer Research UK anati: "Kumvetsetsa ku maselo kuchititsa kukula chotupa mu akazi ndi chibadwa olakwika BRCA1 zingachititse kuti mankhwala atsopano kuchepetsa chiopsezo amayamba khansa, kupereka akazi awa njira ina kuchepetsa chiopsezo chawo. Koma phunziro ili zinachitikadi mu mbewa ndi maselo labu, kotero ife sitikudziwa momwe ogwira njira imeneyi angakhale pa kuchepetsa m'mawere kansa mu akazi, kapena momwe izo zikufanana ndi options kupewa amene ali kale alipo. "

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