Mis Cancer ntawm kev loj hlob Halted los ntawm tus kab mob hauv tshuaj

Breast Cancer Cell Growth Halted by Osteoporosis Drug

Ib lub rooj plaub nyob hauv nas lawm hais tias cov tshuaj denosumab yuav ua mis Translation kev kho mob rau cov poj niam uas BRCA1 noob change


Powered by Guardian.co.ukNo tsab xov xwm hu “Mis kheesxaws ntawm kev loj hlob halted los ntawm tus kab mob hauv tshuaj, txoj kev tshawb no qhia tau hais tias” yog sau ntawv los Ian qauv Science editor, rau tus saib xyuas rau hnub Monday May 20th 2016 15.40 UTC

Cov poj niam uas muaj tus ntxim mob cancer ntawm lub mis yuav zoo los ntawm ib cov tshuaj uas twb ob los kho cov txha nyob laus, raws li tej zaum nyob rau Australia.

Soj ntsuam ntawm pom tias tus kab mob hauv tshuaj, denosumab, tau txoj kev loj hlob ntawm lub hlwb uas muab ntxiv rau ntawm lub mis tumours rau cov poj niam uas nws yuav raug tus kab mob no yog qhov ntau dua vim noob rau hauv ib lub noob uas hu ua BRCA1 nres.

Ho pheej, lub chaw ua hauj lwm yog tsi thiab soj ntsuam gleaned li far from cov kev kuaj (lab) ntawm cov nas thiab tej nqaij mos rau ntawm lub mis yuav tsum ua tswv cuab rau cov neeg raug coob ua ntej cov tshuaj yuav tau ua tus kho mob uas tiv thaiv.

Noj qab nyob zoo BRCA1 thiab BRCA2 noob pab lub cev kho lawm DNA. Tab sis, thaum twg yog noob mutated, ntawm cov mis thiab qog nqaij hlav ntawm zes qe menyuam yuav sawv steeply. Ib nrab ntawm cov poj niam uas inherit muaj teeb meem hloov BRCA1 los BRCA2 yuav pib mob cancer ntawm lub mis uas muaj hnub nyoog 70.

Cov poj niam uas nrhiav pom muaj teeb meem BRCA change tau opt rau Translation phais tshem nws ob lub mis, los yog tau muab ntau txoj kev ntsuas rau tumours. "Peb tau pom zoo xav kom nrhiav tau ib qho kev xaiv alternation, ib tug tsis yog phais mus kom ze rau cov poj niam,"hais Emma Nolan tom Walter and Eliza nrog lub koom haum ntawm kev tshawb fawb hauv Victoria.

Cov analysed kua ntswg pub nws los ntawm ib tug poj niam mob BRCA1 change. Ntawm no, ib pab tias loj hlob thiab nyob tau precursors ntawm ob lub mis tumours tsum cais lawv.

Kev xeem ntxiv ntawm lub hlwb ices tias lawv ris kev muaj protein ntau marker rau ntawm qhov chaw, hu ua RANK1. Protein tib targeted ntawm denosumab, uas yog twb siv kheesxaws txha thiab cov kua uas puas tau kis rau tus pob txha.

Nyob rau hauv (lab) kev kuaj hauv cov phau ntawv journal Tshuaj xwm, denosumab sim txoj kev loj hlob ntawm lub mob cancer precursor hlwb thiab xav tau qeeb hauv kev loj hlob ntawm tumours nyob hauv nas bred tsim mob cancer ntawm lub mis.

"Peb cov pog heev los ntawm cov kev tshawb pom vim nws txhais tau hais tias peb twb nrhiav tau ib tug zoo uas tej zaum yuav pab tau kom tsis txhob mob rau cov poj niam ntxim heev, feem ntau yog BRCA1 hloov muaj,"hais Geoff Lindeman, oncologist kho mob nyob hauv lub tsev kho mob Melbourne muaj koob muaj npe. Nws hais tias sim soj ntsuam mus ntsuam xyuas tau cov tshuaj nyob rau hauv tus neeg mob tau twb pib.

Emma Smith ntawm Cancer Research UK hais: "Insights mus ua tus molecules yuav ua tumour loj rau cov poj niam uas muaj faulty BRCA1 noob yuav ua rau muaj kev kho tshiab tsis txhob mob huam mob cancer ntawm lub mis, muab cov poj niam yuav xaiv ib los txo lawv yuav raug. Tiam sis txoj kev tshawb no yog kwv hauv nas thiab rau ntawm lub hlwb ntawm ib, li ntawd, peb tsis paub zoo npaum li cas kauj yuav rau txo cov uas yuav muaj mob cancer mis rau cov poj niam, los yog li cas yuav muab piv nrog rau txoj kev tiv thaiv uas twb muaj."

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