Tāimu'a Engineers maimoatanga mate pukupuku pūnaha ārai mate ki te whawhai mate

Pioneering cancer treatment engineers immune systems to fight disease

 

Powered e Guardian.co.ukTēnei tuhinga ui “Tāimu'a Engineers maimoatanga mate pukupuku pūnaha ārai mate ki te whawhai mate” i tuhituhia e Haroon Siddique, hoki theguardian.com i runga i te Wenerei te 9 o Hakihea 2015 14.50 UTC

Tūroro ki te matenga, me te mate pukupuku kaki e te fariiraa i te maimoatanga hou repo e ngā ue'i ratou pūnaha ārai mate ki te whawhai i te mate.

Ko te tamataraa, i te National Institute hoki Health Research pokapū rangahau biomedical i a Guy ko St Thomas 'NHS turanga whakawhirinaki me Kingi o College London, Ko tā te ira whakarerekētia tūroro 'ma pūtau toto kia mohio ratou, ka patu i te puku.

E fakanatula rawa pūtau toto White o te pūnaha ārai mate ki te whakakore i ngā pūtau - mea rawa huaketo - e kore e waiho i reira, engari i ētahi wā te hiahia āwhina ki te mohio ki a pūtau whakaeke mate pukupuku.

Mā te whakamahi i te tauira toto, Kei te penei te kapa BRC ma pūtau toto i roto i te taiwhanga ki te huaketo kinokore e whakamōhio ira hou e rua. hanga te ira tuatahi reira māmā ki te tupu i te pūtau i roto i to ratou wa i roto i te taiwhanga i te tuarua taea te pūtau ma toto ki te mohio ki a te patu i te puku.

ka mea fiefanongo Tumuaki Dr John Maher: "I roto i te nuinga o mate pukupuku, metastasis, te horapa o te mate i te wahi o te tinana i te wahi tīmata te reira ki tetahi atu e kore e hono hāngai, Ko te take commonest o te mate. Heoi, He rerekē i roto i taua horapa rohe ranei hohokitanga o nga kaute mate mo te nuinga o te mauiui, me te mate matenga, me te mate pukupuku kaki. tikanga o tēnei kia meinga pukupuku mahi tika, me te kaua e holomui i roto i te whakautu ki te maimoatanga tuku iho pērā i hahau iraruke ranei ".

huaina te maimoatanga te he T-pūtau CAR a e rua wiki ki te whakaputa i. Ki te whakanui i tona haumaru me te whai huatanga kei te injecting te kapa te CAR T-pūtau tika ki te puku. Kua kï CAR maimoatanga T pūtau-whai hua i roto i te tahi mau huru o te kanisā ko te tumanako he e taea te whakawhanake reira atu ki whai hua tūroro ki pera-ka karanga "mate pukupuku totoka", e hanga i te puranga puku motuhake, pērā i te matenga, me te kaki mate pukupuku.

ka mea a Mahereharara angitu i taea e whai "pānga nui hoki te tahi atu pukupuku totoka, rawa te hunga e horahia i roto i te wāhi tūturu i roto i te tinana, pērā i te mate pukupuku ovarian (ararewa o te puku) mesothelioma ranei (ararewa o nga pūkahukahu). I roto i taua tautuhinga, pea e taea ki te wero i te CAR T-pūtau i te manawanui tika ki te kōhao, ki te localize te maimoatanga te wahi e hiahiatia ana e ia te nuinga ".

I roto i te wā 1 tamataraa, e whai ana ki te whakamatautau haumaru me te whai huatanga o te maimoatanga, tūroro whakauru i roto i ngā rōpū ä ka riro he maha teitei o ngā pūtau ki whakapumautia inenga haumaru, mehemea e kore e te reira hua i nui taha-pānga. Ki te he te reira angitu, ka hiahia te maimoatanga ki te kia whakamatauria i roto i ngā tau nui o tūroro ki te whakapumautia pehea whai hua ko reira i tohe te mate pukupuku.

Dr Stephen Caddick, kaiwhakahaere o innovations i te Wellcome Trust, e tahi-pūtea te tamataraa, mea: "Na pū engineering pūtau ārai ki te mohio ki a te whakangaro pukupuku, He ti'aturi e, e taea ki te whakapai ake i te opuaraa no te tūroro e to ratou kairangahau, noa i teie nei, fehangahangai rawa iti kōwhiringa maimoatanga. "

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