Growth Cell uma Cancer totitoti ana e Osteoporosis Drug

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whakaaturia te tamataraa i roto i kiore kua e taea te denosumab tarukino hei te maimoatanga mate pukupuku uma taupā mō wahine ki irakētanga BRCA1 ira


Powered e Guardian.co.ukTēnei tuhinga ui “Uma mate pukupuku tupu pūtau totitoti ana e osteoporosis tarukino, whakaaturanga ako” e Ian etita Pūtaiao Tauira i tuhituhia, mo te Guardian ki te Mane 20 o Pipiri 2016 15.40 UTC

kia whai hua nga wahine e whai he mōrea nui o te mate pukupuku uma i te tarukino kua i whakaritea ki te hamani mate wheua i roto i te tau tawhito, rite ki kaipūtaiao i Ahitereiria.

kitea kairangahau e te tarukino osteoporosis, denosumab, Ka taea e aukati i te tupu o ngā pūtau e hoatu ara ki te pukupuku uma i roto i nga wahine nei mōrea o te mate he nui no te irakētanga i roto i te BRCA1 ira huaina.

ahakoa fafau, Ko te mahi i te wā wawe a me tāruatia nga hua hamu na matara i whakamātautau taiwhanga i runga i kiore, me te kiko uma i roto i te mau tamataraa rahi tangata i mua i taea te whakaaro te tarukino ano he maimoatanga taupā.

Hauora BRCA1 me BRCA2 ira tauturu i te DNA hanga tinana pakaru. Otira ka rānei ira mutated te, te mōrea o te uma me te ovarian mate pukupuku taea whakatika steeply. Mō te hawhe o te wahine e whiwhi i te irakētanga kino i roto i te BRCA1 BRCA2 ranei ka whakawhanake mate pukupuku uma i te tau o 70.

Women e ite ratou te kawe e taea irakētanga BRCA kino whakaputa hoki pokanga taupā ki te tango io ratou uma, whai atu āta kaha mō te pukupuku ranei. "I matou hiahia i roto i te imiraa i te kōwhiringa whakarerekētanga, he huarahi kore-hāparapara hoki enei wahine,"Ka mea a Emma Nolan i te Walter me Eliza Hall Institute o Medical Research i Victoria.

Nga pūtaiao tātarihia kiko uma takoha i te wahine pāngia ki irakētanga BRCA1. Mai i tenei, taratahi ratou he rōpū motuhake o te pūtau i tupu oioi ka puta ki te hei precursors o te pukupuku uma.

whakamātautau atu o nga pūtau whakakitea e kawea e ratou he tohu pūmua i runga i te mata, i huaina RANK1. hāngai te taua pūmua e denosumab, nei whakamahia kē ki te hamani osteoporosis me te uma pukupuku kua horapa nei ki te wheua.

I roto i te whakamātautau taiwhanga korerotia i roto i te buka aamu Nature Medicine, āraia denosumab te tupu o nga pūtau kawainga pukupuku, a pakanga te tupu o te pukupuku i roto i kiore muia ki te whakawhanake i te mate pukupuku uma.

"Ko te tino oaoa i enei kitenga tatou no te mea te auraa kua kitea e matou i te rautaki e ai kia whai hua ki te ārai mate pukupuku uma i roto i nga wahine mōrearea tiketike rawa, Tino kawe BRCA1 irakētanga,"Ka mea a Geoff Lindeman, he matepukupuku rānei hauora i te Melbourne Hospital Royal. ka mea ia, kua tīmata kē te tamataraa haumanu ki te aromatawai i te raau taero i roto i te tūroro.

ka mea a Emma Smith i Cancer Rangahau UK: "Insights ki te rāpoi ngota meinga tupu puku i roto i nga wahine ki te ira BRCA1 hē taea arahi ki maimoatanga hou whakaiti i te mōrea o te whakawhanake i te mate pukupuku uma, hoatu enei wahine tetahi kōwhiringa ki raro to ratou mōrea. Ko kawea tenei ako i roto i roto i kiore, me te i runga i ngā pūtau i roto i te taiwhanga, na e kore matou e mohio me pehea whai hua i taea e tenei huarahi kia i whakaiti mōrea pukupuku uma i roto i nga wahine, ranei pehea whakataurite reira ki kōwhiringa mō te ārai e te hunga kua wātea. "

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