Pušenje visoke čvrstoće kanabis može oštetiti živčana vlakna u mozgu

Smoking high-strength cannabis may damage nerve fibres in brain

 

Pokreće Guardian.co.ukOvaj članak pod naslovom “Pušenje visoke čvrstoće kanabis može oštetiti živčana vlakna u mozgu” napisao je Ian uzorka znanosti urednika, The Guardian u petak, 27. studenog 2015 00.01 UTC

Visoke čvrstoće kanabis može oštetiti živčana vlakna koja obrađuju tijek poruka preko dvije polovice mozga, Znanstvenici tvrde. Skeniranje mozga ljudi koji redovito pušile jak tvor-poput kanabisa revealed subtle differences in the white matter that connects the left and right hemispheres and carries signals from one side of the brain to the other.

The changes were not seen in those who never used cannabis or smoked only the less potent forms of the drug, the researchers found.

The study is thought to be the first to look at the effects of cannabis potency on brain structure, and suggests that greater use of skunk may cause more damage to the corpus callosum, čineći komunikaciju preko hemisfere mozga manje učinkovitih.

Paola Dazzan, neurobiologist na Institutu za psihijatriju s Kraljevskog koledža u Londonu, rekao učinci pojavili bi biti povezan s razinom aktivne tvari, tetrahidrokanabinol (THC), u marihuane. Dok tradicionalni oblici kanabisa sadrži 2 za 4 % THC, Moćniji sorte (kojih ima oko 100), može sadržavati 10 za 14% THC, prema DrugScope ljubavi.

"Ako pogledate na corpus callosum, what we’re seeing is a significant difference in the white matter between those who use high potency cannabis and those who never use the drug, or use the low-potency drug,” said Dazzan. The corpus callosum is rich in cannabinoid receptors, on which the THC chemical acts.

A DTI image of the corpus callosum, as seen from the side, is shown in red on and superimposed on a background MRI image of the brain.
A DTI image of the corpus callosum, as seen from the side, is shown in red on and superimposed on a background MRI image of the brain. Fotografirati: Institute of Psychiatry

“The difference is there whether you have psychosis or not, a mi da je to isključivo odnosi na potenciju od kanabisa,", Dodala je. Detalji istraživanja su objavljeni u časopisu Psihološka medicina.

Istraživači su koristili dvije tehnike skeniranja, magnetska rezonancija (MR) i difuzija tenzor imaging (DTI), ispitati corpus callosum, najveće područje bijele tvari, u mozgovima 56 pacijenti koji su izvijestili prvu epizodu psihoze, a 43 zdravi dobrovoljci iz lokalne zajednice.

The scans found that daily users of high-potency cannabis had a slightly greater – by about 2% – “mean diffusivity” in the corpus callosum. “That reflects a problem in the white matter that ultimately makes it less efficient,” Dazzan told the Guardian. “We don’t know exactly what it means for the person, but it suggests there is less efficient transfer of information.”

The study cannot confirm that high levels of THC in cannabis cause changes to white matter. As Dazzan notes, to može biti da ljudi s oštećenim bijele tvari su više vjerojatno da će pušiti timove na prvom mjestu.

"Moguće je da su ti ljudi već imaju drugačiji mozak i oni su više vjerojatno da će koristiti marihuanu. No, ono što možemo reći je li to visoka potenciju, i ako pušite često, tvoj mozak je drugačiji od mozga nekim tko puši marihuanu normalan, i od nekoga tko ne puši kanabis uopće,"Rekla je.

But even with the uncertainty over cause and effect, she urged users and public health workers to change how they think about cannabis use. “When it comes to alcohol, we are used to thinking about how much people drink, and whether they are drinking wine, pivo, or whisky. We should think of cannabis in a similar way, in terms of THC and the different contents cannabis can have, and potentially the effects on health will be different,"Rekla je.

“As we have suggested previously, when assessing cannabis use, izuzetno je važno prikupiti podatke o tome koliko često i što tip kanabisa se koristi. Ovi detalji mogu pomoći kvantificirati rizik od psihičkih problema i povećati svijest o vrsti oštećenja te tvari može učiniti na mozgu,", Dodala je.

U veljači, Dazzan i drugi na Institutu za psihijatriju izvijestio da je spreman dostupnost tvor u južnom Londonu moglo biti iza porast udjela novih slučajeva psihoze se pripisati kanabisu.

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