Caj ntaub ntawv Tej zaum Pab Peb To taub Txoj kev ua neej txaus ntshai rau Kab Mob

Genetic Information Might Help Us Understand Lifestyle Risks for Disease

Caj variants twv lom yuav raug rau tus kab mob, tab sis lawv tej zaum kuj yuav tau qhia rau peb hais txog heritable tus cwj pwm uas yuav muaj yam


Powered by Guardian.co.ukQhov tsab xov xwm hu ua “Caj ntaub ntawv yuav pab kom peb to taub txoj kev ua neej txaus ntshai rau tus kab mob” raug sau los ntawm Suzi Gage, rau theguardian.com rau hnub Monday 22nd Lub ob hlis ntuj 2016 13.16 UTC

Thaum koj nyeem cov khoom tau thov kev pab hais tias muaj ib tug xov tooj ntawm cov noob uas twv seb ib tug kab mob, feem ntau yog cov ntaub ntawv no los ntawm genome-dav koom haum kev tshawb fawb (GWAS). Cov hypothesis-free analyses siv loj tus xov tooj ntawm cov neeg, thiab saib rau cov koom haum ua teb ntawm ib tug kab mob thiab kev tshuaj ntsuam genetic variations nyob rau hauv ntau pua pua txhiab tus qhov chaw thoob plaws lub genome.

Tab sis paub hais tias muaj 108 kev tshuaj ntsuam genetic qhov chaw txuam nrog schizophrenia yog tsis tas uas pab tau tshwj tsis yog tias koj paub dab tsi no caj variants tau ua. GWAS yog ib tug kev tshawb fawb lub cuab tam, ib txoj kev uas pab peb to taub ib tug kab mob. Tej zaum nws yog lub npe hu hais tias ib tug variant lis dej num rau ib tug protein, thiab ces tus muaj nuj nqi ntawm uas noob yog yooj yim kom to taub, tab sis thaum lub caij lom nuj nqi ntawm ib tug ntau ntawm kev tshuaj ntsuam genetic variants cia li yog tsis paub, limiting siv ntawm GWAS raws li ib tug kev tshawb fawb lub cuab tam.

Nws tau raug assumed tias kev tshuaj ntsuam genetic variants qhia los ntawm GWAS sawv cev ncaj qha, lom muaj tej yam ib tug kab mob - lub "qhov" es "tu" kawg ntawm kev pheej hmoo. Kuv lug txhawb cov miv thiab kuv muaj nyuam qhuav luam tawm ib daim ntawv nyob rau hauv uas peb hais tias muaj tej zaum yuav xav paub ntxiv tshaj li uas muaj nyob hauv cov kev tshwm sim.

Thaum ib tug GWAS mob cancer twb tau soj xyuas, ib tug kev tshuaj ntsuam genetic variant uas tau txuam nrog mob ntsws cancer yog ib tug paub variant nyob tsis pub dhau ib cheeb tsam ntawm chromosome 15 hu ua lub "nicotine acetylcholine noob receptor pawg". Qhov no variant tau pom tias yuav tsum tau txuas mus rau lub xov tooj ntawm cov luam yeeb haus luam yeeb ib hnub twg, nyob rau hauv cov neeg uas haus luam yeeb. Thaum nws yuav ua tau cov ntaub ntawv uas cov noob kuj nws tus kheej yuav ua tau kom mob ntsws cancer, raws li zoo raws li heaviness ntawm kev haus luam yeeb, no mas, deb ntau yuav hais tias qhov no variant yog qhia nyob rau hauv lub GWAS rau mob ntsws cancer vim hais tias haus luam yeeb ua rau mob cancer.

Muaj lwm tug piv txwv zoo nyob rau hauv lub cawv ntaub ntawv. Ib tug kev tshuaj ntsuam genetic variant tau qhia tias kwv yees cawv noj. Nws lis dej num rau ib tug protein uas lov lom metabolites ntawm cawv rau hauv uas tsis yog-tshuaj lom sawv daws yuav. Yog hais tias koj tsis muaj ntau npaum li cas ntawm qhov no protein, theem ntawm toxins yuav txhim tsa, ua rau koj xav tias mob thiab flushed. Lub variant tsis yog heev nyob rau hauv European neeg, tab sis yog xav paub ntau ntau nyob rau hauv coob ntawm East Asian poj koob yawm txwv. Nyob rau hauv cov pab pawg, GWAS ntawm ntshav siab qhia no xyov cawv txog genotype. Tab sis nws tsis tau pom nyob rau hauv GWAS ntawm ntshav siab nyob rau hauv European neeg. Qhov no yog haum muaj zog ua pov thawj tias cawv noj tej zaum yuav ua rau kom ntshav siab.

Cov kev tshawb nrhiav coj mus rau ib qho kev nthuav thought: tej zaum, raws li zoo raws li kev pom zoo causal koom haum ua teb peb twb paub (zoo li kev haus luam yeeb thiab mob ntsws cancer), nws yuav pab tau peb kom paub tias lwm causal muaj tej yam kab mob. Piv txwv li, tib neeg haus luam yeeb variant twb tseem qhia nyob rau hauv ib tug tsis ntev los no GWAS ntawm schizophrenia - tej zaum yuav no txhais tau hais tias haus luam yeeb yog ib tug causal uas muaj feem yuav tau rau tus kab mob? tejzaum nws, txawm tias ntxiv kev soj ntsuam yuav tsum tau kom paub meej tias qhov no, raws li nws cov tseem tau qhov no yuav tsum tau muab qhia genetic architecture.

Thaum lub caij, lub ntsiab kev txwv nyob rau hauv txhais GWAS nyob rau hauv no txoj kev yog hais tias muaj yog tsis heev muaj ntau yam kev tshuaj ntsuam genetic twv tau ntawm modifiable muaj tej yam qhia. Tab sis qhov no yog hloov. Piv txwv li, peb paub tias cannabis siv yog tsawg kawg yog ib nrab heritable, tawm tswv yim muaj yog ib caj tivthaiv, tab sis raws li tseem tsis muaj variants tau lawm tias. Thaum cov variants pib raug pom, cov ntaub ntawv nyob rau hauv GWAS yuav qhib tau rau peb.

Thiab yog vim li cas yog no pab tau? Zoo, nws yog yooj yim npaum li mus pab tau cov neeg hloov lawv txoj kev ua neej coj yeeb yam nws yog hloov lawv noob caj noob ces!

guardian.co.uk © Tus Saib Xyuas Xov xwm & Media Limited 2010