Mis Cancer Cell loj hlob nres los ntawm Txha Drug

Breast Cancer Cell Growth Halted by Osteoporosis Drug

A sim nyob rau hauv nas lawm hais tias cov tshuaj denosumab yuav los ua ib tug tiv thaiv lub mis mob cancer kho mob rau cov poj niam nrog BRCA1 noob change


Powered by Guardian.co.ukQhov tsab xov xwm hu ua “Tus mob cancer mis cell loj hlob nres los ntawm txha tshuaj, txoj kev tshawb no qhia tau hais tias” raug sau los ntawm Ian Sample Science editor, rau Tus Saib Xyuas rau hnub Monday 20th Lub rau hli ntuj 2016 15.40 UTC

Cov poj niam uas muaj lub siab mob cancer mis tej zaum yuav tau txais txiaj ntsim los ntawm ib tug yeeb tshuaj uas yog twb tua tau kho cov pob txha tsis nyob rau hauv cov laus hnub nyoog, raws li zaum nyob rau hauv teb chaws Australia.

Tshawb fawb pom tias cov kab mob hauv cov tshuaj, denosumab, yuav nres txoj kev loj hlob ntawm lub hlwb uas muab sawv mus mis hlav nyob rau hauv cov poj niam uas nws yuav raug ntawm tus kab mob yog ntau dua vim hais tias ntawm change nyob rau hauv ib lub noob hu ua BRCA1.

Tab sis yog pheej, lub chaw ua hauj lwm yog nyob rau ntawm ib thaum ntxov rau theem thiab kev soj ntsuam gleaned kom deb li deb los ntawm lab xeem rau nas thiab cov kua ntswg yuav tsum tau ua dua nyob rau hauv loj tib neeg tej kev txom nyem ua ntej cov tshuaj yuav suav hais tias raws li ib tug tiv thaiv kev kho mob.

Healthy BRCA1 thiab BRCA2 noob pab tau lub cev kho puas DNA. Tab sis thaum yog noob yog mutated, kev pheej hmoo ntawm lub mis thiab ntawm zes qe menyuam qog nqaij hlav yuav sawv steeply. Hais txog ib nrab ntawm cov poj niam uas muaj ib yam teeb meem hloov nyob rau hauv BRCA1 los yog BRCA2 yuav tsim ob lub mis mob cancer los ntawm cov muaj hnub nyoog ntawm 70.

Cov poj niam uas nrhiav tau lawv nqa teeb meem BRCA change yuav opt rau tiv thaiv kev phais kom tshem tawm nws ob lub mis, los yog muaj ntau intensive kev kuaj rau hlav. "Peb twb xav nrhiav ib tug alternation kev xaiv, ib tug uas tsis yog-phais mus kom ze rau cov poj niam,"Hais tias Emma Nolan nyob rau Walter thiab Eliza Hall lub koom haum ntawm Medical Research nyob rau hauv Victoria.

Lub zaum analyzed kua ntswg pub los ntawm ib tug poj niam mob BRCA1 change. Los ntawm no, lawv cais ib cov pab pawg neeg cov hlwb uas loj hlob sai heev thiab tshwm sim yuav tsum tau precursors ntawm lub mis hlav.

Ntxiv kev soj ntsuam ntawm lub hlwb qhia hais tias lawv nqa ib tug protein marker rau ntawm qhov chaw, hu ua RANK1. Cov tib protein yog tsom los ntawm denosumab, uas yog twb siv los kho txha thiab ob lub mis mob cancer uas tau kis mus rau tus pob txha.

Nyob rau hauv lab xeem qhia nyob rau hauv cov phau ntawv journal xwm tshuaj, denosumab sim loj hlob ntawm cov mob cancer precursor hlwb thiab tub ceevxwm txoj kev loj hlob ntawm cov qog nyob rau hauv nas bred los tsim lub mis mob cancer.

"Peb cov pog los ntawm cov kev tshawb pom vim hais tias nws txhais tau tias peb twb pom ib lub tswv yim uas tej zaum yuav pab tau los mus tiv thaiv lub mis mob cancer nyob rau hauv heev uas yuav muaj cov poj niam, tshwj xeeb BRCA1 hloov nqa,"Hais tias Geoff Lindeman, ib tug kho mob oncologist ntawm lub noob nom noob tswv Melbourne tsev kho mob. Nws hais tias ib tug soj ntsuam mus sib rau kev ntsuam xyuas cov tshuaj rau cov neeg mob twb pib.

Emma Smith ntawm Cancer Research UK hais tias: "Insights rau hauv lub lwg me me yuav ua tau lub pob loj hlob nyob rau hauv cov poj niam nrog faulty BRCA1 noob yuav ua tau kom tshiab kev kho mob kom txhob muaj txoj kev pheej hmoo ntawm lub mis mob cancer, muab cov poj niam lwm cov kev xaiv kom txo tau lawv yuav raug. Tab sis txoj kev tshawb no twb nqa tawm nyob rau hauv nas thiab nyob rau hlwb nyob rau hauv lub lab, li ntawd, peb tsis paub yuav ua li cas zoo no mus kom ze yuav tau txo lub mis mob cancer nyob rau hauv cov poj niam, los yog yuav ua li cas nws muab piv nrog kev xaiv rau kev tiv thaiv uas twb muaj. "

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