Nono Cell Girmancin tsayar da osteoporosis Drug

Breast Cancer Cell Growth Halted by Osteoporosis Drug

A fitina a mice ya nuna cewa da miyagun ƙwayoyi denosumab iya zama preventative nono magani ga mata da BRCA1 gene maye gurbi


Powered by Guardian.co.ukWannan labarin mai taken “Nono cell girma tsayar da osteoporosis miyagun ƙwayoyi, binciken shows” ya rubuta Ian Sample Science edita, for The Guardian a ranar Litinin 20th Yuni 2016 15.40 UTC

Matan da suka yi wani babban hadarin nono iya amfana daga wani magani da aka riga wajabta mu bi da kashi hasãra a cikin tsufa, bisa ga masana kimiyya a Australia.

Masu bincike gano cewa osteoporosis miyagun ƙwayoyi, denosumab, iya dakatar da ci gaban da Kwayoyin wadda ba Yunƙurin zuwa nono marurai a mata wanda hadarin cutar ne mafi girma saboda maye gurbi a cikin wani gene kira BRCA1.

Ko da yake alamar, aikin ne a wani wuri mataki da kuma sakamakon gleaned ya zuwa yanzu daga Lab gwaje-gwaje a kan mice da nono nama dole ne a sake bugawa a manyan mutum gwaji da miyagun ƙwayoyi za a iya gani a matsayin wani preventative magani.

Healthy BRCA1 da BRCA2 genes taimaka jiki gyara lalace DNA. To, a lõkacin da ko dai gene ne mutated, hadarin nono da kuma ovarian cancers iya tashi steeply. Game da rabi na matan da suka gada a cutarwa maye gurbi a cikin BRCA1 ko BRCA2 za su ci gaba da nono da shekaru 70.

Matan da suka samu da suka kawo illa BRCA maye gurbi iya ficewa domin preventative tiyata don cire kirãzansu, ko da more m nunawa ga marurai. "Mun kasance interested in gano wani canzawar wani zaɓi, maras m m na wadannan mata,"Ya ce Emma Nolan a Walter kuma Eliza Hall Cibiyar Medical Research in Victoria.

The masana kimiyya bincikar nono nama bayar daga wata mace kamu da BRCA1 maye gurbi. daga wannan, suka ware wani jinsin rukuni na Kwayoyin cewa girma cikin sauri da kuma bayyana ga zama precursors na nono marurai.

Bugu da ari, jarrabawa daga cikin sel bayyana cewa sun dauki mai gina jiki alama a kan surface, kira RANK1. Haka gina jiki da aka yi niyya daga denosumab, wanda aka riga amfani da su bi osteoporosis da nono wadda ta watsu cikin kashi.

A Lab gwaje-gwaje ya ruwaito a cikin mujallar Nature Medicine, denosumab katange ci gaban da ciwon daji precursor Kwayoyin da ragae ci gaban da ciwace-ciwacen daji a mice bred wajen samar da nono.

"Mu ne sosai m da wadannan binciken domin shi yana nufin mun sãmi wani dabarun da zai zama da amfani a hana nono a sosai high hadarin mata, Musamman BRCA1 maye gurbi dako,"Ya ce Geoff Lindeman, wani likita oncologist a Royal Hospital Melbourne. Ya ce a asibiti fitina tantance da miyagun ƙwayoyi a marasa lafiya ya riga ya fara.

Emma Smith a Cancer Research UK ce: "Basirar cikin kwayoyin haddasa ciwon daji girma a cikin mata da karkatattun BRCA1 kwayoyin halittu zai iya haifar da sabon jiyya rage hadarin tasowa nono, bada wadannan mata wani zabin su runtse daga hadarin. Amma wannan binciken da aka za'ayi a mice kuma a kan Kwayoyin a cikin Lab, don haka ba mu san yadda tasiri wannan m zai iya zama a rage hadarin nono a mata, ko yadda kwantanta da zaɓuɓɓuka saboda rigakafin da suke riga available. "

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